Electroporation based therapeutics


 
Objective: To advance gene therapy through electroporation technology, enabling in vivo production of therapeutic proteins directly within patient tissues.
Overview: This project focuses on developing a combination platform device that integrates electroporation with cellular machinery to deliver therapeutic plasmid DNA, inducing targeted cells to produce specific proteins. Our innovative approach holds promise for on-demand protein production within the body, potentially reducing the need for frequent injections and improving therapeutic efficacy for various diseases. Our therapeutic electroporation devices are being designed for both human and animal applications, aiming to make gene therapy more accessible and effective.
Applications: In vivo gene therapy, protein replacement therapy, cancer immunotherapy, and personalized medicine. 

Publications


Enhancing In Vivo Electroporation Efficiency through Hyaluronidase: Insights into Plasmid Distribution and Optimization Strategies


Debnath Maji, Veronica Miguela, Andrew D Cameron, Delcora A Campbell, Linda Sasset, Xin Yao, Andy T Thompson, Carleigh Sussman, David Yang, Robert Miller, others

Pharmaceutics, vol. 16, MDPI, 2024, p. 547


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